Scientists developed a light-responsive artificial nucleic acid that enables reversible, controllable crosslinking within DNA, opening doors for nanomedicine, DNA nanotechnologies and drug delivery.

Thioguanosine (shown as S in the sequence) is placed at nearby, non-complementary positions within a DNA duplex. When exposed to light or mild oxidants, the modified bases react to form a disulfide ...

Newly developed DNA nanostructures can form flexible, fluid, and stimuli-responsive condensates without relying on chemical cross-linking, report researchers from the Institute of Science Tokyo and ...