•Hypoxia-inducible factors (HIFs) regulate genes involved in angiogenesis, invasion and metabolic reprogramming, essential for cancer progression. •HIF-1α triggers metabolic changes, including the ...

Researchers show that pharmacological activation of hypoxia signaling improves metabolism, limits fat accumulation, and restores bone health in obese mice Obesity is widely known for increasing the ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...

Obesity is widely known for increasing the risk of diabetes and cardiovascular disease, but its damaging effects on the skeleton are often overlooked. Excess body fat can disrupt bone metabolism, ...