Nature

Network centric identification of PI3K/Akt hub proteins as key oncogenic drivers and therapeutic targets

The PI3K/Akt pathway plays a central role in cancer progression by regulating cell proliferation, survival, and metabolism. Dysregulation of this pathway, often due to mutations in genes such as ...
Nature

Gedatolisib shows superior potency and efficacy versus single-node PI3K/AKT/mTOR inhibitors in breast cancer models

The PI3K, AKT, and mTOR (PAM) pathway is frequently dysregulated in breast cancer (BC) to accommodate high catabolic and anabolic activities driving tumor growth. Current therapeutic options for ...
ascopubs.org

Clinical outcomes of patients with PI3K pathway alterations by treatment type: The MD Anderson Cancer Center IMPACT 2 study.

This is an ASCO Meeting Abstract from the 2026 ASCO Annual Meeting I. This abstract does not include a full text component.
ascopubs.org

Subtype-specific PI3K-pathway and TP53 alteration patterns in breast cancer: A cross-cohort comparison of TCGA-BRCA and AACR GENIE.

Reversible epigenetic control of CD146 phenotypic states in MDA-MB-231 breast cancer cells. Real-world outcomes in patients (pts) with metastatic breast cancer (MBC) treated with trastuzumab ...
The American Journal of Managed Care

Low-Dose Aspirin Cuts Recurrence Risk in PI3K-Altered Colorectal Cancer

Low-dose aspirin significantly reduced colorectal cancer recurrence in patients with PI3K pathway gene alterations, nearly halving recurrence rates over three years compared to placebo. The study ...