A series of structures of the eukaryotic protein-synthesis machinery are imaged at high resolution in defined states of the elongation phase of protein synthesis. Analysis suggests that there are ...

In the earliest phase of creating human proteins, the protein complex NAC performs an essential task by starting the first steps toward folding proteins into their correct three-dimensional structures ...

Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of ...

The diagram illustrates the key stages of protein synthesis in a eukaryotic cell. It begins with transcription to produce pre-mRNA in the nucleus (1), followed by post-transcriptional modification (2) ...

The discovery of ribosomes dates back to the 1950s, when George Palade first observed dense particles in the cytoplasm of cells using electron microscopy. These particles were later named "ribosomes" ...

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

In a new study, published in Cell, researchers describe a newfound mechanism for creating proteins in a giant DNA virus, comparable to a mechanism in eukaryotic cells. The finding challenges the dogma ...

Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal aspartic and glutamic acid residues in eukaryotic ...