Gut

The UK experience with hepatitis B immunoglobulin use following liver transplantation: wide variation in practice despite evidence supporting cost-effectiv…

Introduction Hepatitis B immunoglobulin (HBIG) and nucleos(t)ide analogues (NA) are standard prophylaxis against hepatitis B ...
Gut

Norepinephrine promotes tumour cell aggressiveness and NK cell ferroptosis via ADRB2 in intrahepatic cholangiocarcinoma with perineural invasion

Background Sympathetic signalling plays a critical role in the initiation and progression of various malignancies. However, ...
Gut

Loss of sinusoidal endothelial identity: RAP1A at the crossroads of capillarisation and liver fibrosis

Liver fibrosis represents a serious worldwide health issue with a prevalence of around 5% in general populations.1 The most ...
gut.bmj

Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis

Objective: To investigate differential intestinal gene expression in patients with ulcerative colitis and in controls. Design: Genome-wide expression study (41 058 expression sequence tags, 215 ...
gut.bmj

Cyclooxygenase 2—implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives

Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and ...
gut.bmj

Development of an index to define overall disease severity in IBD

Background and aim Disease activity for Crohn's disease (CD) and UC is typically defined based on symptoms at a moment in time, and ignores the long-term burden of disease. The aims of this study were ...
gut.bmj

Inflammation of the gastro-oesophageal junction (carditis) in patients with symptomatic gastro-oesophageal reflux disease: a prospective study

Department of Medicine, Division of Digestive Diseases and Gastroenterology, UCLA Medical Centre and Beth Israel Deaconess Medical Centre, Los Angeles, California, USA Dr T Lembo, Beth Israel ...
gut.bmj

Vedolizumab affects antibody responses to immunisation selectively in the gastrointestinal tract: randomised controlled trial results

Correspondence to Dr Tim Wyant, Takeda Pharmaceuticals International Co, 40 Landsdowne St, Cambridge, MA 02139, USA; Tim.Wyant{at}takeda.com Design In this randomised, double-blind, placebo-controlled ...
gut.bmj

IDDF2024-ABS-0130 Faecalibacterium prausnitzii antagonizes helicobacter pylori colonization and inhibits gastric carcinogenesis

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The ...
gut.bmj

Rectal compliance and rectal sensation in constipated adolescents, recovered adolescents and healthy volunteers

1 Department of Pediatric Gastroenterology and Nutrition, Emma Children’s Hospital Academic Medical Centre, Amsterdam, The Netherlands 2 Department of Gastroenterology, Academic Medical Centre, ...
gut.bmj

Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats

1 Gastroenterology Unit, Université Catholique de Louvain (UCL), Brussels, Belgium 2 Pathology Unit, Université Catholique de Louvain (UCL), Brussels, Belgium Correspondence to: Professor I Leclercq ...
gut.bmj

Bowel preparation and the risk of explosion during colonoscopic polypectomy.

Concentration of oxygen, methane, and hydrogen were measured in intracolonic gas samples aspirated through the colonoscope at the time of colonoscopy from 46 patients. Of the above patients 20 ...