Programmed cell death is a controlled process that removes damaged or unneeded cells. Mitochondria play a central role in this process. Although they are known for energy production, they also store internal signals that can begin cell death when necessary. When a cell becomes severely stressed or damaged, proteins inside the mitochondria change their behavior. These proteins cause the outer mitochondrial membrane to become more open. Once the membrane opens, the mitochondria release signaling m
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