Protein Design Principles Revealed in AI Analysis of Nanoribbon Assembly
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A diffusion model for protein design – Institute for Protein Design
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MIT engineers design proteins by their motion, not just their shape
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The next frontier in protein design will not be defined by structure alone, but by the capacity to engineer motion as a first-class principle of function. This is because dynamics is where the real biology lives.Foundational work by Karplus, Levitt & Warshel made clear that chemistry cannot be understood without motion, mechanism, and scale. Gō, Brooks & others showed that proteins possess characteristic collective motions - low-frequency normal modes that capture how whole molecules bend, breat
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